Chemical assay-guided natural product isolation via solid-supported chemodosimetric fluorescent probe.
نویسندگان
چکیده
As a new model of chemical assay-guided natural product isolation, an effective chemodosimetric assay system was devised. Our chemical assay system features a fluorogenic chemodosimeter immobilized on a solid support, which offers advantages in identifying the desired compounds in complex natural product mixtures. To isolate only compounds with the target functional groups, the click chemistry concept was adopted. The model system presented here was developed for natural products with a terminal alkyne. Using our newly designed alkyne sensing beads with the aforementioned features, we have readily identified, quantified, and isolated compounds with a terminal alkyne group from plant extracts.
منابع مشابه
Chemical assay-guided natural product isolation via solid-supported chemodosimetric fluorescent probe† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc00360a Click here for additional data file.
As a new model of chemical assay-guided natural product isolation, an effective chemodosimetric assay system was devised. Our chemical assay system features a fluorogenic chemodosimeter immobilized on a solid support, which offers advantages in identifying the desired compounds in complex natural product mixtures. To isolate only compounds with the target functional groups, the click chemistry ...
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ورودعنوان ژورنال:
- Chemical science
دوره 6 5 شماره
صفحات -
تاریخ انتشار 2015